The Healthcare Cost and Utilization Project (HCUP) Statistical Brief – Characteristics of Inpatient Hospital Stays Involving Sickle Cell Disease, 2000-2016 – presents statistics on inpatient stays among patients with Sickle Cell Disease (SCD). Historical trends are presented by patient age from 2000 through 2016 using the National (Nationwide) Inpatient Sample (NIS). Characteristics of inpatient stays with and without SCD are examined in 2016, overall and by whether SCD (i.e., a principal diagnosis) or a secondary diagnosis (i.e., a condition that coexists at the time of the inpatient stay) was the reason for the stay. SCD-related stays are examined with respect to whether a pain crisis was present. Additionally, costs, length of stay, and 30-day all-cause readmission rates following stays involving SCD are provided. Finally, the location of inpatient hospital care for patients with SCD is shown.